Open AccessMesenchymal Stem Cells Provide an Advantageous Tumor Microenvironment for the Restoration of Cancer Stem Cells
Author(s) -
Kanako Nishimura,
Shuho Semba,
Kazuhiko Aoyagi,
Hiroki Sasaki,
Hiroshi Yokozaki
Publication year - 2012
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000337296
Subject(s) - mesenchymal stem cell , cancer research , wnt signaling pathway , cancer stem cell , stem cell , microbiology and biotechnology , biology , stromal cell , population , chemistry , medicine , signal transduction , environmental health
Accumulating evidences suggest that cancer-associated fibroblasts are provided from bone-marrow-derived mesenchymal stem cells (BM-MSCs); however, little is known about the mechanism(s) by which BM-MSCs accelerate cancer aggressiveness.
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