Thyroid Cancer: Role of RET and Beyond | Zendy

Francesca Carlomagno | Zendy

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Thyroid Cancer: Role of RET and Beyond

Author(s) -

Francesca Carlomagno

Publication year - 2012

Publication title -

european thyroid journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.23

H-Index - 10

eISSN - 2235-0802

pISSN - 2235-0640

DOI - 10.1159/000336975

Subject(s) - medicine , carcinogenesis , thyroid carcinoma , medullary thyroid cancer , proto oncogene proteins c ret , thyroid cancer , cancer research , multiple endocrine neoplasia type 2 , medullary cavity , thyroid , gene , medullary carcinoma , cancer , mutation , pathology , genetics , germline mutation , biology , receptor , glial cell line derived neurotrophic factor , neurotrophic factors

Specific thyroid cancer histotypes, such as papillary and medullary thyroid carcinoma, display genetic rearrangements or point mutations of the RET gene, resulting in its oncogenic conversion. The molecular mechanisms mediating RET rearrangement with other genes and the role of partner genes in tumorigenesis have been described. In addition, the RET protein has become a molecular target for medullary thyroid carcinoma treatment.

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