Natural Product Extract of Dicksonia sellowiana Induces Endothelium-Dependent Relaxations by a Redox-Sensitive Src- and Akt-Dependent Activation of eNOS in Porcine Coronary Arteries | Zendy

Yanna Dantas Rattmann | Zendy; Eric Anselm | Zendy; Jong Hun Kim | Zendy; S. Dal-Ros | Zendy; Cyril Auger | Zendy; Obdúlio Gomes Miguel | Zendy; Adair R.S. Santos | Zendy; Thierry Chataigneau | Zendy; Valérie B. SchiniKerth | Zendy

Open Access

Natural Product Extract of<b><i> Dicksonia sellowiana</i></b> Induces Endothelium-Dependent Relaxations by a Redox-Sensitive Src- and Akt-Dependent Activation of eNOS in Porcine Coronary Arteries

Author(s) -

Yanna Dantas Rattmann,

Eric Anselm,

Jong Hun Kim,

S. Dal-Ros,

Cyril Auger,

Obdúlio Gomes Miguel,

Adair R.S. Santos,

Thierry Chataigneau,

Valérie B. SchiniKerth

Publication year - 2012

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000336647

Subject(s) - wortmannin , enos , protein kinase b , endothelium , chemistry , phosphorylation , catalase , medicine , pharmacology , endocrinology , biochemistry , biology , nitric oxide synthase , oxidative stress , enzyme

The consumption of polyphenol-rich food is associated with a decreased mortality from coronary diseases. This study examined whether a standardized hydroalcoholic extract of Dicksonia sellowiana (HEDS) triggered endothelium-dependent relaxations in porcine coronary artery rings and characterized the underlying mechanism.

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