Inflammatory Regulators of Redirected Neural Migration in the Injured Brain | Zendy

Nicole Bye | Zendy; Ann M. Turnley | Zendy; Maria Cristina Morganti-Kossmann | Zendy

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Inflammatory Regulators of Redirected Neural Migration in the Injured Brain

Author(s) -

Nicole Bye,

Ann M. Turnley,

Maria Cristina Morganti-Kossmann

Publication year - 2012

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000336542

Subject(s) - subventricular zone , traumatic brain injury , neuroblast , neuroscience , chemokine , neuroinflammation , neural stem cell , medicine , neurogenesis , inflammation , biology , immunology , microbiology and biotechnology , stem cell , psychiatry

Brain injury following stroke or trauma induces the migration of neuroblasts derived from subventricular zone neural precursor cells (NPCs) towards the damaged tissue, where they then have the potential to contribute to repair. Enhancing the recruitment of new cells thus presents an enticing prospect for the development of new therapeutic approaches to treat brain injury; to this end, an understanding of the factors regulating this process is required. During the neuroinflammatory response to ischemic and traumatic brain injuries, a plethora of pro- and anti-inflammatory cytokines, chemokines and growth factors are released in the damaged tissue, and recent work indicates that a variety of these are able to influence injury-induced migration. In this review, we will discuss the contribution of specific chemokines and growth factors towards stimulating NPC migration in the injured brain.

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