Differential Sleep-Wake Sensitivity of Gonadotropin-Releasing Hormone Secretion to Progesterone Inhibition in Early Pubertal Girls | Zendy

Jessicah S Collins | Zendy; John C. Marshall | Zendy; Christopher R. McCartney | Zendy

Open Access

Differential Sleep-Wake Sensitivity of Gonadotropin-Releasing Hormone Secretion to Progesterone Inhibition in Early Pubertal Girls

Author(s) -

Jessicah S Collins,

John C. Marshall,

Christopher R. McCartney

Publication year - 2012

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000336395

Subject(s) - endocrinology , medicine , luteinizing hormone , morning , gonadotropin , gonadotropin releasing hormone , hormone , pulse (music) , biology , physics , detector , optics

Early pubertal luteinizing hormone (LH), and by inference gonadotropin-releasing hormone (GnRH), pulse secretion is marked by high nocturnal but low daytime frequency; however, the underlying mechanisms remain unclear. Plasma concentrations of progesterone, the major regulator of GnRH frequency in women, increase in the early morning in early pubertal girls and may help slow daytime GnRH frequency.

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