A Critical Role for the Inducible Proteasomal Subunits LMP7 and MECL1 in Cytokine Production by Activated Murine Splenocytes | Zendy

Cheryl E. Rockwell | Zendy; John J. Monaco | Zendy; Nilofer Qureshi | Zendy

Open Access

A Critical Role for the Inducible Proteasomal Subunits LMP7 and MECL1 in Cytokine Production by Activated Murine Splenocytes

Author(s) -

Cheryl E. Rockwell,

John J. Monaco,

Nilofer Qureshi

Publication year - 2012

Publication title -

pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.51

H-Index - 59

eISSN - 1423-0313

pISSN - 0031-7012

DOI - 10.1159/000336335

Subject(s) - proteasome , cytokine , ionomycin , microbiology and biotechnology , biology , lactacystin , splenocyte , immunology , proteasome inhibitor , immune system , intracellular

The proteasome is a multi-subunit complex that proteolytically cleaves proteins. The replacement of the constitutive proteasome subunits β1, β2, and/or β5 with the IFNγ-inducible subunits LMP2, MECL1, and/or LMP7 results in the 'immunoproteasome'. The inducible subunits change the cleavage specificities of the proteasome, but it is unclear whether they have functions in addition to this. The purpose of the present study was to determine the role of the proteasome in general, as well as LMP7 and MECL1 specifically, with regard to cytokine production by activated primary splenocytes.

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