Identification of the Translation Start Site of the Human Melanocortin 3 Receptor | Zendy

Patrick Tarnow | Zendy; Anne Rediger | Zendy; Angela Schulz | Zendy; Annette Grüters | Zendy; Heike Biebermann | Zendy

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Identification of the Translation Start Site of the Human Melanocortin 3 Receptor

Author(s) -

Patrick Tarnow,

Anne Rediger,

Angela Schulz,

Annette Grüters,

Heike Biebermann

Publication year - 2012

Publication title -

obesity facts

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.398

H-Index - 45

eISSN - 1662-4033

pISSN - 1662-4025

DOI - 10.1159/000336070

Subject(s) - melanocortin 3 receptor , start codon , receptor , coding region , genetics , complementary dna , translation (biology) , melanocortin , biology , gene , microbiology and biotechnology , messenger rna , melanocortin receptor

The melanocortin-3-receptor (MC3R) is a G-protein coupled receptor participating in hypothalamic energy metabolism. So far, it was assumed that the translation of the human MC3R starts at the non-conserved first ATG, however, a second evolutionary conserved ATG is located 37 amino acids downstream. One frequent polymorphism, T6K, is located between these two ATGs.

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