Stress Resistance in the Naked Mole-Rat: The Bare Essentials – A Mini-Review | Zendy

Kaitlyn N. Lewis | Zendy; James Mele | Zendy; Peter J. Hornsby | Zendy; Rochelle Buffenstein | Zendy

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Stress Resistance in the Naked Mole-Rat: The Bare Essentials – A Mini-Review

Author(s) -

Kaitlyn N. Lewis,

James Mele,

Peter J. Hornsby,

Rochelle Buffenstein

Publication year - 2012

Publication title -

gerontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.397

H-Index - 94

eISSN - 1423-0003

pISSN - 0304-324X

DOI - 10.1159/000335966

Subject(s) - resistance (ecology) , mole , psychology , gerontology , medicine , biology , ecology

Studies comparing similar-sized species with disparate longevity may elucidate novel mechanisms that abrogate aging and prolong good health. We focus on the longest living rodent, the naked mole-rat. This mouse-sized mammal lives ~8 times longer than do mice and, despite high levels of oxidative damage evident at a young age, it is not only very resistant to spontaneous neoplasia but also shows minimal decline in age-associated physiological traits.

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