The Gastrin-Releasing Peptide Receptor as a Marker of Dysplastic Alterations in Cervical Epithelial Cells | Zendy

Daniela Baumann Cornélio | Zendy; Luíse Meurer | Zendy; Gilberto Schwartsmann | Zendy; Rafael Roesler | Zendy

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The Gastrin-Releasing Peptide Receptor as a Marker of Dysplastic Alterations in Cervical Epithelial Cells

Author(s) -

Daniela Baumann Cornélio,

Luíse Meurer,

Gilberto Schwartsmann,

Rafael Roesler

Publication year - 2012

Publication title -

oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.987

H-Index - 98

eISSN - 1423-0232

pISSN - 0030-2414

DOI - 10.1159/000335955

Subject(s) - immunocytochemistry , cervical cancer , medicine , immunostaining , dysplasia , ascus (bryozoa) , immunohistochemistry , pathology , cervical intraepithelial neoplasia , cancer , intraepithelial neoplasia , prostate cancer , biology , botany , ascospore , spore

Cervical cancer is a leading cancer in women worldwide. The Papanicolaou test (Pap test) remains the main screening tool; however, it produces high rates of false-negative and false-positive results. Gastrin-releasing peptide is a growth factor that has been implicated in many cancers, and its main receptor, the gastrin-releasing peptide receptor (GRPR), is nearly always expressed in cervical dysplasias and invasive carcinomas. The aim of this study was to evaluate the diagnostic potential of GRPR immunocytochemistry in detecting cervical dysplasia and invasive cancer.

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