Tissue Plasminogen Activator Expression and Barrier Properties of Human Brain Microvascular Endothelial Cells | Zendy

Fan Yang | Zendy; Shuo Liu | Zendy; ShurJen Wang | Zendy; Chuanhui Yu | Zendy; Annlia PaganiniHill | Zendy; Mark Fisher | Zendy

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Tissue Plasminogen Activator Expression and Barrier Properties of Human Brain Microvascular Endothelial Cells

Author(s) -

Fan Yang,

Shuo Liu,

ShurJen Wang,

Chuanhui Yu,

Annlia PaganiniHill,

Mark Fisher

Publication year - 2011

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000335785

Subject(s) - occludin , blood–brain barrier , tight junction , tissue plasminogen activator , endothelial stem cell , plasminogen activator , forskolin , endocrinology , vascular permeability , endothelium , chemistry , plasminogen activator inhibitor 1 , medicine , biology , microbiology and biotechnology , in vitro , biochemistry , central nervous system

Tissue plasminogen activator (tPA) regulates fibrinolysis and is routinely used as ischemic stroke pharmacotherapy. We hypothesized that brain microvascular tPA expression and barrier properties of endothelial cells are substantially related.

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