Atorvastatin Inhibits Functional Expression of Proatherogenic TLR2 in Arterial Endothelial Cells | Zendy

Cristina Bertocchi | Zendy; Michaela Traunwieser | Zendy; Jakob Dörler | Zendy; Julia Haßlacher | Zendy; Michael Joannidis | Zendy; Stefan Dunzendorfer | Zendy

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Atorvastatin Inhibits Functional Expression of Proatherogenic TLR2 in Arterial Endothelial Cells

Author(s) -

Cristina Bertocchi,

Michaela Traunwieser,

Jakob Dörler,

Julia Haßlacher,

Michael Joannidis,

Stefan Dunzendorfer

Publication year - 2011

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000335758

Subject(s) - tlr2 , atorvastatin , endothelial stem cell , phosphorylation , microbiology and biotechnology , endothelial dysfunction , western blot , flow cytometry , proinflammatory cytokine , biology , endocrinology , chemistry , medicine , immunology , signal transduction , inflammation , biochemistry , in vitro , gene , tlr4

There is growing evidence that TLR2 plays a role in the pathogenesis of atherosclerosis. It is highly expressed in endothelial cells in areas of disturbed blood flow, like plaques or vessel bifurcations, but laminar blood flow suppresses endothelial TLR2 expression and is therefore thought to be atheroprotective. We sought for means to also protect lesion prone sites from TLR2 over-expression and subsequent endothelial activation.

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