Mitochondria Distinguish Granule-Stored from de novo Synthesized Tumor Necrosis Factor Secretion in Human Mast Cells | Zendy

Bodi Zhang | Zendy; Zuyi Weng | Zendy; Nikolaos Sismanopoulos | Zendy; Sharhzad Asadi | Zendy; Anastasia Therianou | Zendy; Konstantinos–Dionysios Alysandratos | Zendy; Asimenia Angelidou | Zendy; Orian S. Shirihai | Zendy; Theoharis C. Theoharides | Zendy

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Mitochondria Distinguish Granule-Stored from de novo Synthesized Tumor Necrosis Factor Secretion in Human Mast Cells

Author(s) -

Bodi Zhang,

Zuyi Weng,

Nikolaos Sismanopoulos,

Sharhzad Asadi,

Anastasia Therianou,

Konstantinos–Dionysios Alysandratos,

Asimenia Angelidou,

Orian S. Shirihai,

Theoharis C. Theoharides

Publication year - 2012

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000335178

Subject(s) - degranulation , tumor necrosis factor alpha , secretion , microbiology and biotechnology , mast cell , biology , immune system , mitochondrion , chemistry , immunology , biochemistry , receptor

Mast cells are immune cells derived from hematopoietic precursors that mature in the tissue microenvironment. Mast cells are critical for allergic, immune and inflammatory processes, many of which involve tumor necrosis factor (TNF). These cells uniquely store TNF in their secretory granules. Upon stimulation, mast cells rapidly (30 min) secrete β-hexosaminidase and granule-stored TNF through degranulation, but also increase TNF mRNA and release de novo synthesized TNF 24 h later. The regulation of these two distinct pathways is poorly understood.

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