Validity, Significance, Strengths, Limitations, and Evidentiary Value of Real-World Clinical Data for Combination Therapy in Alzheimer’s Disease: Comparison of Efficacy and Effectiveness Studies | Zendy

Alireza Atri | Zendy; Susan Rountree | Zendy; Oscar L. López | Zendy; Rachelle S. Doody | Zendy

Open Access

Validity, Significance, Strengths, Limitations, and Evidentiary Value of Real-World Clinical Data for Combination Therapy in Alzheimer’s Disease: Comparison of Efficacy and Effectiveness Studies

Author(s) -

Alireza Atri,

Susan Rountree,

Oscar L. López,

Rachelle S. Doody

Publication year - 2012

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000335156

Subject(s) - memantine , randomized controlled trial , medicine , observational study , placebo , disease , intensive care medicine , clinical psychology , dementia , alternative medicine , pathology

Randomized controlled efficacy trials (RCTs), the scientific gold standard, are required for regulatory approval of Alzheimer's disease (AD) interventions, yet provide limited information regarding real-world therapeutic effectiveness.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research