Analysis of Cellular Localization and Function of Carboxy-Terminal Mutants of Pendrin | Zendy

Aigerim Bizhanova | Zendy; Teng-Leong Chew | Zendy; Satya Khuon | Zendy; Peter Kopp | Zendy

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Analysis of Cellular Localization and Function of Carboxy-Terminal Mutants of Pendrin

Author(s) -

Aigerim Bizhanova,

Teng-Leong Chew,

Satya Khuon,

Peter Kopp

Publication year - 2011

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000335105

Subject(s) - pendrin , forskolin , chemistry , efflux , apical membrane , epithelial polarity , biochemistry , microbiology and biotechnology , endocrinology , medicine , biophysics , biology , membrane , transporter , receptor , gene

Iodide uptake at the basolateral membrane and iodide efflux at the apical membrane of thyrocytes, essential steps in the biosynthesis of thyroid hormone, are stimulated by thyroid stimulating hormone (TSH). Pendrin (SLC26A4) is inserted into the apical membrane of thyrocytes and thought to be involved in mediating iodide efflux.

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