Analysis of p16CDKN2A Methylation and HPV-16 Infection in Oral Mucosal Dysplasia | Zendy

Thiago Fonseca–Silva | Zendy; Lucyana Conceição Farias | Zendy; Cláudio Marcelo Cardoso | Zendy; Ludmilla Regina de Souza | Zendy; Carlos Alberto de Carvalho Fraga | Zendy; Marcos Vinícius Macêdo de Oliveira | Zendy; Lucas Oliveira Barros | Zendy; Lucas Rodrigues Alves | Zendy; Alfredo Maurício Batista de Paula | Zendy; Luciano Marques-Silva | Zendy; Ricardo Santiago Gomez | Zendy; André Luiz Sena Guimarães | Zendy

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Analysis of p16<sub><i>CDKN2A</i></sub> Methylation and HPV-16 Infection in Oral Mucosal Dysplasia

Author(s) -

Thiago Fonseca–Silva,

Lucyana Conceição Farias,

Cláudio Marcelo Cardoso,

Ludmilla Regina de Souza,

Carlos Alberto de Carvalho Fraga,

Marcos Vinícius Macêdo de Oliveira,

Lucas Oliveira Barros,

Lucas Rodrigues Alves,

Alfredo Maurício Batista de Paula,

Luciano Marques-Silva,

Ricardo Santiago Gomez,

André Luiz Sena Guimarães

Publication year - 2012

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000334926

Subject(s) - methylation , dna methylation , dnmt3b , microbiology and biotechnology , biology , methyltransferase , gene expression , dna , gene , genetics

The purpose of this study was to investigate the relationship between p16(CDKN2A) methylation and epithelial dysplasia (ED). We also evaluated the expressions of proteins related to methylation (DNMT3B and DNMT1). Finally, we tested whether HPV-16/18 or the dmt3b (C46359T) polymorphism is associated with p16(CDKN2A) methylation status.

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