Clearance of Amyloid-β Protein Deposits in Transgenic Mice following Focal Cerebral Ischemia | Zendy

William E. Van Nostrand | Zendy; Jennifer Davis | Zendy; Mary Lou Previti | Zendy; Feng Xu | Zendy

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Clearance of Amyloid-β Protein Deposits in Transgenic Mice following Focal Cerebral Ischemia

Author(s) -

William E. Van Nostrand,

Jennifer Davis,

Mary Lou Previti,

Feng Xu

Publication year - 2012

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000334763

Subject(s) - ischemia , microglia , genetically modified mouse , medicine , pathology , stroke (engine) , infiltration (hvac) , cerebral amyloid angiopathy , brain ischemia , amyloid (mycology) , amyloid precursor protein , transgene , alzheimer's disease , inflammation , biology , disease , dementia , biochemistry , mechanical engineering , physics , engineering , gene , thermodynamics

There is increased amyloid-β protein precursor (AβPP) expression and amyloid-β protein (Aβ) production in the brain shortly following cerebral ischemic stroke in rodent models. It has been postulated that this may seed amyloid deposition in the brain. On the other hand, it remains unclear how cerebral ischemia affects preexisting Aβ deposits in the brain. Here we determine the consequences of focal ischemic stroke on existing Aβ pathology in Tg-SwDI transgenic mice.

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