Roles of Milk Fat Globule-Epidermal Growth Factor 8 in Intestinal Inflammation | Zendy

Ryusaku Kusunoki | Zendy; Shunji Ishihara | Zendy; Monowar Aziz | Zendy; Akihiko Oka | Zendy; Yasumasa Tada | Zendy; Yoshikazu Kinoshita | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Roles of Milk Fat Globule-Epidermal Growth Factor 8 in Intestinal Inflammation

Author(s) -

Ryusaku Kusunoki,

Shunji Ishihara,

Monowar Aziz,

Akihiko Oka,

Yasumasa Tada,

Yoshikazu Kinoshita

Publication year - 2012

Publication title -

digestion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.882

H-Index - 75

eISSN - 1421-9867

pISSN - 0012-2823

DOI - 10.1159/000334679

Subject(s) - inflammation , immune system , epidermal growth factor , biology , microbiology and biotechnology , apoptosis , phosphatidylserine , immunology , growth factor , function (biology) , biochemistry , receptor , phospholipid , membrane

Milk fat globule-epidermal growth factor 8 (MFG-E8), a glycoprotein secreted from various cells, enhances engulfment of apoptotic cells by forming a link between phosphatidylserine on apoptotic cells and α(v)β(3)-integrin on phagocytes. This process is essential for maintaining the host immune system under physiological conditions. Apart from this scavenging function, MFG-E8 also directly regulates a variety of cellular functions, such as attenuating inflammation and healing of injured tissues. Furthermore, recent studies have revealed that MFG-E8 has anti-inflammatory and regenerating roles during intestinal inflammation. This review highlights novel findings regarding the roles of MFG-E8 in intestinal pathophysiology as well as its therapeutic potential for gut inflammatory disorders.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research