Functional Mannose-Binding Lectin Levels in Patients with End-Stage Renal Disease on Maintenance Hemodialysis | Zendy

Atsushi Satomura | Zendy; Takayuki Fujita | Zendy; Mitsuru Yanai | Zendy; Kazunari Kumasaka | Zendy; Yuki Uehara | Zendy; Kazuyoshi Okada | Zendy; Yoshinobu Fuke | Zendy; Tomohiro Nakayama | Zendy

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Functional Mannose-Binding Lectin Levels in Patients with End-Stage Renal Disease on Maintenance Hemodialysis

Author(s) -

Atsushi Satomura,

Takayuki Fujita,

Mitsuru Yanai,

Kazunari Kumasaka,

Yuki Uehara,

Kazuyoshi Okada,

Yoshinobu Fuke,

Tomohiro Nakayama

Publication year - 2012

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000334601

Subject(s) - mannan binding lectin , hemodialysis , lectin , end stage renal disease , immunology , medicine , gastroenterology , disease , biology

Innate immunity is generally impaired in chronic renal failure (CRF). Mannose-binding lectin (MBL) has an important role in first-line host defense against pathogens via the lectin pathway. We recently reported that functional MBL was significantly lower in CRF patients than in healthy subjects. In this study, we aimed to determine whether functional MBL would be improved following hemodialysis (HD) therapy.

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