Polymorphisms in 1-Carbon Metabolism, Epigenetics and Folate-Related Pathologies | Zendy

Patrick J. Stover | Zendy

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Polymorphisms in 1-Carbon Metabolism, Epigenetics and Folate-Related Pathologies

Author(s) -

Patrick J. Stover

Publication year - 2011

Publication title -

lifestyle genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.542

H-Index - 30

eISSN - 2504-3188

pISSN - 2504-3161

DOI - 10.1159/000334586

Subject(s) - epigenetics , dna methylation , chromatin , biology , homocysteine , methylation , genetics , metabolism , methionine , gene , biochemistry , gene expression , amino acid

Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and result from nutritional deficiencies and common gene variants. The mechanisms underlying folate-associated pathologies and developmental anomalies have yet to be established. This review focuses on the relationships among folate-mediated 1-carbon metabolism, chromatin methylation and human disease, and the role of gene-nutrient interactions in modifying epigenetic processes.

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