Estrogen Receptor-Beta Variants Are Associated with Increased Risk of Alzheimer’s Disease in Women with Down Syndrome | Zendy

Qi Zhao | Zendy; Joseph H. Lee | Zendy; Deborah Pang | Zendy; Alexis M. Temkin | Zendy; Naeun Park | Zendy; Sarah Janicki | Zendy; Warren B. Zigman | Zendy; Wayne Silverman | Zendy; Benjamin Tycko | Zendy; Nicole Schupf | Zendy

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Estrogen Receptor-Beta Variants Are Associated with Increased Risk of Alzheimer’s Disease in Women with Down Syndrome

Author(s) -

Qi Zhao,

Joseph H. Lee,

Deborah Pang,

Alexis M. Temkin,

Naeun Park,

Sarah Janicki,

Warren B. Zigman,

Wayne Silverman,

Benjamin Tycko,

Nicole Schupf

Publication year - 2011

Publication title -

dementia and geriatric cognitive disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.026

H-Index - 110

eISSN - 1421-9824

pISSN - 1420-8008

DOI - 10.1159/000334522

Subject(s) - single nucleotide polymorphism , endocrinology , medicine , estrogen , estrogen receptor , estrogen receptor alpha , estrogen receptor beta , allele , alzheimer's disease , biology , disease , genotype , genetics , gene , breast cancer , cancer

Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). We examined the relation of polymorphisms in the gene for the estrogen receptor-beta (ESR2) to the risk of AD in women with Down syndrome.

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