Measuring Genome Instability in Aging – A Mini-Review | Zendy

Wenge Li | Zendy; Jan Vijg | Zendy

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Measuring Genome Instability in Aging – A Mini-Review

Author(s) -

Wenge Li,

Jan Vijg

Publication year - 2011

Publication title -

gerontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.397

H-Index - 94

eISSN - 1423-0003

pISSN - 0304-324X

DOI - 10.1159/000334368

Subject(s) - genome instability , biology , somatic cell , mutation , genetics , mutation accumulation , genome , chromosome instability , premature aging , transgene , endogeny , genetically modified mouse , dna damage , gene , dna , chromosome , endocrinology

There is mounting evidence for an age-dependent accumulation of somatic mutations as a result of the inherent imperfection of DNA replication and repair. A possible age-related decline in genome maintenance systems may exacerbate this age-related loss of genome integrity. A review of the current methods of mutation detection is timely in view of the lack of insight as to the magnitude of somatic mutation accumulation, the types of mutations that accumulate, and their functional consequences.

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