Using DNA Methylation to Understand Biological Consequences of Genetic Variability | Zendy

Dena Hernández | Zendy; Andrew Singleton | Zendy

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Using DNA Methylation to Understand Biological Consequences of Genetic Variability

Author(s) -

Dena Hernández,

Andrew Singleton

Publication year - 2011

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000333097

Subject(s) - epigenetics , context (archaeology) , dna methylation , computational biology , biology , argument (complex analysis) , genetic architecture , data science , genetics , computer science , evolutionary biology , cognitive science , psychology , gene , phenotype , gene expression , paleontology , biochemistry

The advent of high-content genomic mapping technologies has provided numerous clues about the genetic architecture of complex disease and the tools with which to understand the biological framework resulting from this architecture. We believe that understanding and mapping epigenetic marks, in particular DNA methylation, which is suited to such assays, offers a timely opportunity in this context. Here, we make an argument for this work, describing this opportunity, the likely path ahead, and the problems and pitfalls associated with such work.

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