Use of Diffusion Tensor MRI to Identify Early Changes in Diabetic Nephropathy | Zendy

Lan Lŭ | Zendy; John R. Sedor | Zendy; Vikas Gulani | Zendy; Jeffrey R. Schelling | Zendy; Alicia O’Brien | Zendy; Chris A. Flask | Zendy; Katherine MacRae Dell | Zendy

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Use of Diffusion Tensor MRI to Identify Early Changes in Diabetic Nephropathy

Author(s) -

Lan Lŭ,

John R. Sedor,

Vikas Gulani,

Jeffrey R. Schelling,

Alicia O’Brien,

Chris A. Flask,

Katherine MacRae Dell

Publication year - 2011

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000333044

Subject(s) - medicine , fractional anisotropy , diffusion mri , medullary cavity , effective diffusion coefficient , diabetic nephropathy , renal function , kidney disease , urology , magnetic resonance imaging , kidney , pathology , endocrinology , radiology

Currently available clinical indicators of kidney disease lack the sensitivity and/or specificity to identify early-stage diabetic nephropathy (DN). Quantitative diffusion magnetic resonance imaging (MRI), specifically diffusion tensor imaging (DTI), has been used to quantify pathophysiologic changes in other organs but has not been well studied in kidney diseases, including DN. The goal of this pilot study was to examine differences in kidney DTI parameters in diabetic subjects versus healthy controls.

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