Expression of a Disintegrin and Metalloprotease in Human Abdominal Aortic Aneurysms | Zendy

Christina Lipp | Zendy; Fabian Lohoefer | Zendy; Christian Reeps | Zendy; Martina Rudelius | Zendy; Markus Baummann | Zendy; Uwe Heemann | Zendy; HansHenning Eckstein | Zendy; Jaroslav Pelisek | Zendy

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Expression of a Disintegrin and Metalloprotease in Human Abdominal Aortic Aneurysms

Author(s) -

Christina Lipp,

Fabian Lohoefer,

Christian Reeps,

Martina Rudelius,

Markus Baummann,

Uwe Heemann,

HansHenning Eckstein,

Jaroslav Pelisek

Publication year - 2012

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000332959

Subject(s) - disintegrin , metalloproteinase , immunohistochemistry , abdominal aortic aneurysm , matrix metalloproteinase , aorta , pathology , histology , medicine , aortic aneurysm , anatomy , aneurysm , surgery

The a disintegrin and metalloprotease (ADAM) family of metalloproteases possesses a proteolytic function and activates various inflammatory factors. Their expression pattern in an abdominal aortic aneurysm (AAA) is as yet unknown. The aim of this study was to make a detailed analysis of the expression of ADAMs 8, 9, 10, 12, 15 and 17, and their tissue inhibitors of metalloprotease (TIMP)-1 and TIMP-3 in patients with AAA.

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