Clinical, Physiological and Anti-Inflammatory Effect of Montelukast in Patients with Cough Variant Asthma
Author(s) -
Masaya Takemura,
Akio Niimi,
Hisako Matsumoto,
Tetsuya Ueda,
Hirofumi Matsuoka,
Masafumi Yamaguchi,
Makiko Jinnai,
Kazuo Chin,
Michiaki Mishima
Publication year - 2011
Publication title -
respiration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.264
H-Index - 81
eISSN - 1423-0356
pISSN - 0025-7931
DOI - 10.1159/000332835
Subject(s) - medicine , montelukast , methacholine , asthma , eosinophil , leukotriene , bronchial hyperresponsiveness , sputum , leukotriene d4 , visual analogue scale , anesthesia , spirometry , salmeterol , gastroenterology , leukotriene receptor , bronchodilator , respiratory disease , lung , pathology , tuberculosis
Cough variant asthma (CVA) is a phenotype of asthma presenting solely with coughing, characterized by airway hyperresponsiveness, eosinophilic inflammation and a cough response to bronchodilators. Leukotriene receptor antagonists (LTRAs) are antiasthma medications with anti-inflammatory and bronchodilatory properties. Although LTRAs exert antitussive effects in CVA, the mechanisms involved are unknown.
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