Regulation of Physiologic Actions of LRRK2: Focus on Autophagy | Zendy

Andrew Ferree | Zendy; Maria Guillily | Zendy; Hu Li | Zendy; Katelyn Smith | Zendy; Aki Takashima | Zendy; Rachel M. Squillace | Zendy; Manfred Weigele | Zendy; James J. Collins | Zendy; Benjamin Wolozin | Zendy

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Regulation of Physiologic Actions of LRRK2: Focus on Autophagy

Author(s) -

Andrew Ferree,

Maria Guillily,

Hu Li,

Katelyn Smith,

Aki Takashima,

Rachel M. Squillace,

Manfred Weigele,

James J. Collins,

Benjamin Wolozin

Publication year - 2011

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000332599

Subject(s) - lrrk2 , autophagy , caenorhabditis elegans , thrashing , biology , parkinson's disease , microbiology and biotechnology , neurodegeneration , neuroscience , mutant , disease , mutation , gene , genetics , medicine , pathology , apoptosis , parallel computing , computer science

Mutations in LRRK2 are associated with familial and sporadic Parkinson's disease (PD). Subjects with PD caused by LRRK2 mutations show pleiotropic pathology that can involve inclusions containing α-synuclein, tau or neither protein. The mechanisms by which mutations in LRRK2 lead to this pleiotropic pathology remain unknown.

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