Independent Regulation of Na+ and K+ Balance by the Kidney | Zendy

María CastañedaBueno | Zendy; Juan Pablo Arroyo | Zendy; Gerardo Gamba | Zendy

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Independent Regulation of Na+ and K+ Balance by the Kidney

Author(s) -

María CastañedaBueno,

Juan Pablo Arroyo,

Gerardo Gamba

Publication year - 2011

Publication title -

medical principles and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.426

H-Index - 45

eISSN - 1423-0151

pISSN - 1011-7571

DOI - 10.1159/000332580

Subject(s) - aldosterone , medicine , sodium , nephron , potassium , kidney , renin–angiotensin system , balance (ability) , endocrinology , epithelial sodium channel , chemistry , organic chemistry , physical medicine and rehabilitation , blood pressure

The understanding of the independent regulation of sodium and potassium by the kidney has remained elusive. Recent evidence now points to dissimilar regulatory mechanisms in ion handling, dependent on the presence of either aldosterone alone or angiotensin II with aldosterone among other factors. This review summarizes past and present information in an attempt to reconcile the current concepts of differential regulation of sodium and potassium balance through the with-no-lysine (K) kinase (WNK) system and the previous knowledge regarding ion transport mechanisms in the distal nephron.

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