Immunolocalization of Sprouty-1 and Sprouty-2 in Developing Rat Lung | Zendy

Shuichi Hashimoto | Zendy; Hiroshi Nakano | Zendy; Yuko Suguta | Zendy; Gurmukh Singh | Zendy; Sikandar L. Katyal | Zendy

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Immunolocalization of Sprouty-1 and Sprouty-2 in Developing Rat Lung

Author(s) -

Shuichi Hashimoto,

Hiroshi Nakano,

Yuko Suguta,

Gurmukh Singh,

Sikandar L. Katyal

Publication year - 2012

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000332215

Subject(s) - western blot , fibroblast growth factor , microbiology and biotechnology , keratinocyte growth factor , immunohistochemistry , biology , chemistry , biochemistry , immunology , receptor , gene

Sprouty, a common antagonist of fibroblast growth factor (FGF) and epidermal growth factor signaling, is a key player regulating tracheal branching and eye development in Drosophila. Four Sprouty homologs have been identified in vertebrates and all share a cysteine-rich region. However, the physiological function(s) of the individual Sprouty homologs is unknown. mRNA of Sprouty homologs is expressed during mouse lung development. In the present study, we investigated the immunolocalization of Sprouty proteins in rat lung at different stages of development.

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