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Although tricyclic antidepressants amoxapine is proposed to target 5-HT and D2 receptors, very few studies have addressed the effect of amoxapine on molecular and cellular mechanisms via receptor pathways. In this study, we test the effect of amoxapine on rat cerebellar granule neurons (CGNs) to address this possibility.

cellular physiology and biochemistry

Amoxapine Inhibits Delayed Outward Rectifier K&lt;sup&gt;+&lt;/sup&gt; Currents in Cerebellar Granule Cells via Dopamine Receptor and Protein Kinase A Activation