Homocysteine Induces Phosphatidylserine Exposure in Cardiomyocytes through Inhibition of Rho Kinase and Flippase Activity | Zendy

Jessica A. Sipkens | Zendy; Nynke E. Hahn | Zendy; Geerten P. van Nieuw-Amerongen | Zendy; Coen D.A. Stehouwer | Zendy; Jan A. Rauwerda | Zendy; Victor W.M. van Hinsbergh | Zendy; Hans W.M. Niessen | Zendy; Paul A.J. Krijnen | Zendy

Open Access

Homocysteine Induces Phosphatidylserine Exposure in Cardiomyocytes through Inhibition of Rho Kinase and Flippase Activity

Author(s) -

Jessica A. Sipkens,

Nynke E. Hahn,

Geerten P. van Nieuw-Amerongen,

Coen D.A. Stehouwer,

Jan A. Rauwerda,

Victor W.M. van Hinsbergh,

Hans W.M. Niessen,

Paul A.J. Krijnen

Publication year - 2011

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000331713

Subject(s) - rhoa , phosphatidylserine , flippase , microbiology and biotechnology , chemistry , rho associated protein kinase , homocysteine , kinase , biochemistry , signal transduction , biology , phospholipid , membrane

Increased levels of homocysteine (Hcy) form an independent risk factor for cardiovascular disease. In a previous study we have shown that Hcy induced phosphatidylserine (PS) exposure to the outer leaflet of the plasma membrane in cardiomyocytes, inducing a pro-inflammatory phenotype. In the present study the mechanism(s) involved in Hcy-induced PS exposure were analyzed.

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