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There are only few studies documenting the long-term outcome of aorto-caval fistula (ACF) in rats, a model of volume overload heart failure (HF). The aim of the present study was to describe HF-related morbidity and mortality, and to examine the relation between cardiac hypertrophy and survival.

The Course of Heart Failure Development and Mortality in Rats with Volume Overload due to Aorto-Caval Fistula