Challenge of Isolated Sputum Cells Supports in vivo Origin of Intolerance Reaction to Aspirin/Non-Steroidal Anti-Inflammatory Drugs in Asthma | Zendy

Ai Higashi | Zendy; Maria Kumlin | Zendy; Noritaka Higashi | Zendy; Kameran Daham | Zendy; Flora Gaber | Zendy; Agneta Lindeberg | Zendy; Anna James | Zendy; Maria Skedinger | Zendy; Ingrid Delin | Zendy; Pär Gyllfors | Zendy; SvenErik Dahlén | Zendy; Barbro Dahlén | Zendy

Open Access

Challenge of Isolated Sputum Cells Supports in vivo Origin of Intolerance Reaction to Aspirin/Non-Steroidal Anti-Inflammatory Drugs in Asthma

Author(s) -

Ai Higashi,

Maria Kumlin,

Noritaka Higashi,

Kameran Daham,

Flora Gaber,

Agneta Lindeberg,

Anna James,

Maria Skedinger,

Ingrid Delin,

Pär Gyllfors,

SvenErik Dahlén,

Barbro Dahlén

Publication year - 2012

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000331433

Subject(s) - immunology , sputum , medicine , asthma , aspirin , in vivo , allergy , tuberculosis , biology , pathology , microbiology and biotechnology

There is no in vitro test to diagnose aspirin-intolerant asthma (AIA). The aim of this study was to test if challenge with aspirin of sputum cells from subjects with AIA triggers the release of cysteinyl leukotrienes (CysLTs), known to be mediators of bronchoconstriction in AIA.

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