Suppression of Retinal Neovascularization by Lentivirus-Mediated Netrin-1 Small Hairpin RNA
Author(s) -
Huizhuo Xu,
Jiaolian Liu,
Siqi Xiong,
Yun-Zheng Le,
Xiaobo Xia
Publication year - 2011
Publication title -
ophthalmic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 54
eISSN - 1423-0259
pISSN - 0030-3747
DOI - 10.1159/000331428
Subject(s) - inner limiting membrane , retinal , neovascularization , retinopathy of prematurity , angiogenesis , retina , small hairpin rna , retinopathy , netrin , biology , medicine , ophthalmology , cancer research , gene knockdown , microbiology and biotechnology , endocrinology , cell culture , neuroscience , genetics , pregnancy , axon guidance , axon , diabetes mellitus , gestational age
The function of netrin-1 in pathological angiogenesis and its role in retinal neovascularization were investigated in the retinas of oxygen-induced retinopathy (OIR) mice by inhibition of netrin-1.
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