The Adventitia: A Progenitor Cell Niche for the Vessel Wall | Zendy

Mark W. Majesky | Zendy; Xiu Rong Dong | Zendy; Virginia J. Hoglund | Zendy; Günter Daum | Zendy; William M. Mahoney | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Adventitia: A Progenitor Cell Niche for the Vessel Wall

Author(s) -

Mark W. Majesky,

Xiu Rong Dong,

Virginia J. Hoglund,

Günter Daum,

William M. Mahoney

Publication year - 2011

Publication title -

cells tissues organs

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.662

H-Index - 82

ISSN - 1422-6405

DOI - 10.1159/000331413

Subject(s) - adventitia , progenitor cell , microbiology and biotechnology , stem cell , progenitor , anatomy , biology , endothelial stem cell , pathology , medicine , in vitro , biochemistry

Recent observations suggest that the adventitial layer of blood vessels exhibits properties resembling a stem/progenitor cell niche. Progenitor cells have been isolated from the adventitia of both murine and human blood vessels with the potential to form endothelial cells, mural cells, osteogenic cells, and adipocytes. These progenitors appear to cluster at or near the border zone between the outer media and inner adventitia. In the mouse, this border zone region corresponds to a localized site of sonic hedgehog signaling in the artery wall. This brief review will discuss the emerging evidence that the tunica adventitia may provide a niche-like signaling environment for resident progenitor cells and will address the role of the adventitia in growth, remodeling, and repair of the artery wall.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research