Pulmonary Endotoxin Tolerance Protects against Cockroach Allergen-Induced Asthma-Like Inflammation in a Mouse Model | Zendy

Sudha Natarajan | Zendy; Jiyoun Kim | Zendy; Jacqueline Bouchard | Zendy; William W. Cruikshank | Zendy; Daniel G. Remick | Zendy

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Pulmonary Endotoxin Tolerance Protects against Cockroach Allergen-Induced Asthma-Like Inflammation in a Mouse Model

Author(s) -

Sudha Natarajan,

Jiyoun Kim,

Jacqueline Bouchard,

William W. Cruikshank,

Daniel G. Remick

Publication year - 2012

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000330896

Subject(s) - immunology , sensitization , cockroach , medicine , eosinophilia , innate immune system , lipopolysaccharide , immunoglobulin e , allergen , methacholine , inhalation , bronchial hyperresponsiveness , allergy , lung , immune system , biology , respiratory disease , antibody , ecology , anatomy

Compounds which activate the innate immune system, such as lipopolysaccharide, are significant components of ambient air, and extremely difficult to remove from the environment. It is currently unclear how prior inhalation of endotoxin affects allergen sensitization. We examined whether lung-specific endotoxin tolerance induction prior to sensitization can modulate the response to allergen.

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