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The impact of mutations in DNA gyrase and topoisomerase IV on minimum inhibitory concentrations (MICs) was investigated to better understand why besifloxacin has a higher potency against Staphylococcus aureus when compared to other fluoroquinolones, which was especially pronounced against ciprofloxacin-resistant isolates.

chemotherapy

Topoisomerase Mutations That Are Associated with High-Level Resistance to Earlier Fluoroquinolones in &lt;i&gt;Staphylococcus aureus&lt;/i&gt; Have Less Effect on the Antibacterial Activity of Besifloxacin