Primary Generalized Glucocorticoid Resistance and Hypersensitivity | Zendy

Evangelia Charmandari | Zendy

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Primary Generalized Glucocorticoid Resistance and Hypersensitivity

Author(s) -

Evangelia Charmandari

Publication year - 2011

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000330759

Subject(s) - glucocorticoid receptor , glucocorticoid , signal transduction , biology , transcription factor , gene , immunology , genetics

The human glucocorticoid receptor (hGR) is a ubiquitously expressed intracellular, ligand-dependent transcription factor, which mediates the action of glucocorticoids and influences physiological functions essential for life. Alterations in the molecular mechanisms of hGR action impair glucocorticoid signal transduction and alter tissue sensitivity to glucocorticoids. This review summarizes the pathophysiology, molecular mechanisms and clinical aspects of primary generalized glucocorticoid resistance (PGGR) and hypersensitivity (PGGH).

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