Toll-Like Receptor 1/2 Stimulation Induces Elevated Interleukin-8 Secretion in Polymorphonuclear Leukocytes Isolated from Preterm and Term Newborn Infants | Zendy

Nathan L. Thornton | Zendy; Mark J. Cody | Zendy; Christian C. Yost | Zendy

Open Access

Toll-Like Receptor 1/2 Stimulation Induces Elevated Interleukin-8 Secretion in Polymorphonuclear Leukocytes Isolated from Preterm and Term Newborn Infants

Author(s) -

Nathan L. Thornton,

Mark J. Cody,

Christian C. Yost

Publication year - 2011

Publication title -

neonatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.399

H-Index - 84

eISSN - 1661-7819

pISSN - 1661-7800

DOI - 10.1159/000330567

Subject(s) - chemokine , tlr2 , proinflammatory cytokine , immunology , inflammation , medicine , interleukin 8 , cytokine , immune system , secretion , innate immune system , toll like receptor

Neonatal neutrophil dysfunction contributes to inflammatory tissue damage in newborn infants. Toll-like receptors (TLRs) activate the innate immune response through recognition of pathogen-associated molecular patterns. Expression and function of TLRs by neonatal neutrophils has not well been characterized.

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