Activation of Arterial Matrix Metalloproteinases Leads to Vascular Calcification in Chronic Kidney Disease | Zendy

Neal X. Chen | Zendy; Kalisha O’Neill | Zendy; Xianming Chen | Zendy; Kraiwiporn Kiattisunthorn | Zendy; Vincent H. Gattone | Zendy; Sharon M. Moe | Zendy

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Activation of Arterial Matrix Metalloproteinases Leads to Vascular Calcification in Chronic Kidney Disease

Author(s) -

Neal X. Chen,

Kalisha O’Neill,

Xianming Chen,

Kraiwiporn Kiattisunthorn,

Vincent H. Gattone,

Sharon M. Moe

Publication year - 2011

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000330175

Subject(s) - calcification , matrix metalloproteinase , kidney disease , medicine , immunostaining , aorta , vascular smooth muscle , extracellular matrix , pathogenesis , endocrinology , zymography , kidney , pathology , biology , immunohistochemistry , biochemistry , smooth muscle

The objective of the current study was to determine if altered regulation of matrix metalloproteinases (MMPs) may predispose to extracellular matrix degradation, facilitating arterial calcification in chronic kidney disease (CKD) using a progressive model of CKD-MBD, the Cy/+ rat.

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