Validation of a Phage Display and Computational Algorithm by Mapping a Conformational Epitope of Bla g 2 | Zendy

Ruby Tiwari | Zendy; Surendra S. Negi | Zendy; Benjamin Braun | Zendy; Werner Braun | Zendy; Anna Pomés | Zendy; Martin D. Chapman | Zendy; Randall M. Goldblum | Zendy; Terumi MidoroHoriuti | Zendy

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Validation of a Phage Display and Computational Algorithm by Mapping a Conformational Epitope of Bla g 2

Author(s) -

Ruby Tiwari,

Surendra S. Negi,

Benjamin Braun,

Werner Braun,

Anna Pomés,

Martin D. Chapman,

Randall M. Goldblum,

Terumi MidoroHoriuti

Publication year - 2011

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000330108

Subject(s) - epitope , epitope mapping , phage display , computational biology , algorithm , biology , computer science , immunology , antibody

Bla g 2, one of the major cockroach allergens, induces a strong IgE response against conformational epitopes, and on reexposure, sensitized individuals often display symptoms of allergic rhinitis and asthma. The aim of the current study was to perform a test of the efficacy of a modified phage display screening, characterization of selected phages and an automated algorithm, EpiSearch, in locating an important conformational epitope.

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