NAD Blocks High Glucose Induced Mesangial Hypertrophy via Activation of the Sirtuins-AMPK-mTOR Pathway | Zendy

Li Zhuo | Zendy; Bo Fu | Zendy; Xueyuan Bai | Zendy; Bin Zhang | Zendy; Lingling Wu | Zendy; Jing Cui | Zendy; Shaoyuan Cui | Zendy; Wei Ribao | Zendy; Xiangmei Chen | Zendy; Guangyan Cai | Zendy

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NAD Blocks High Glucose Induced Mesangial Hypertrophy via Activation of the Sirtuins-AMPK-mTOR Pathway

Author(s) -

Li Zhuo,

Bo Fu,

Xueyuan Bai,

Bin Zhang,

Lingling Wu,

Jing Cui,

Shaoyuan Cui,

Wei Ribao,

Xiangmei Chen,

Guangyan Cai

Publication year - 2011

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000330077

Subject(s) - nad+ kinase , ampk , sirt3 , sirtuin , chemistry , endocrinology , intracellular , pi3k/akt/mtor pathway , sirtuin 1 , medicine , biology , phosphorylation , microbiology and biotechnology , signal transduction , biochemistry , protein kinase a , downregulation and upregulation , enzyme , gene

Since the discovery of NAD-dependent deacetylases, Sirtuins, it has been recognized that maintaining intracellular levels of NAD is crucial for the management of stress-response of cells. Here we show that high glucose(HG)-induced mesangial hypertrophy is associated with loss of intracellular levels of NAD. This study was designed to investigate the effect of NAD on HG-induced mesangial hypertrophy.

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