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Dedifferentiated rabbit vascular smooth muscle cells (SMCs) exhibit similar features to differentiated SMCs when cultured in three-dimensional matrices of type-I collagen called "honeycombs," but the mechanism is unknown. The role of filamin, an actin-binding protein that links actin filaments in SMCs, was investigated.

Degradation of Filamin Induces Contraction of Vascular Smooth Muscle Cells in Type-I Collagen Matrix Honeycombs