Blockade of Mineralocorticoid and Glucocorticoid Receptors Reverses Stress-Induced Motor Impairments | Zendy

Nafisa M. Jadavji | Zendy; Rebecca D. Supina | Zendy; Gerlinde A. S. Metz | Zendy

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Blockade of Mineralocorticoid and Glucocorticoid Receptors Reverses Stress-Induced Motor Impairments

Author(s) -

Nafisa M. Jadavji,

Rebecca D. Supina,

Gerlinde A. S. Metz

Publication year - 2011

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000329988

Subject(s) - glucocorticoid receptor , mineralocorticoid receptor , mifepristone , medicine , endocrinology , glucocorticoid , mineralocorticoid , corticosterone , blockade , antiglucocorticoid , antagonist , open field , receptor , chronic stress , psychology , biology , hormone , pregnancy , genetics

Stress and glucocorticoids can influence movement performance and pathologies of the motor system. The classic notion assumes that the glucocorticoid receptor (GR) mediates the majority of stress-induced behavioral changes. Nevertheless, recent findings have attributed a more prominent role to the mineralocorticoid receptor (MR) in modulating behavior. The purpose of this study was to dissociate the impact of MR versus GR activation in movement and stress-associated motor disruption.

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