The Electrophysiological Effects of Cardiac Glycosides in Human iPSC-derived Cardiomyocytes and in Guinea Pig Isolated Hearts | Zendy

Liang Guo | Zendy; Jian-Yong Qian | Zendy; Rory Abrams | Zendy; Hai-Ming Tang | Zendy; Thomas Weiser | Zendy; Martin Sanders | Zendy; Kyle L. Kolaja | Zendy

Open Access

The Electrophysiological Effects of Cardiac Glycosides in Human iPSC-derived Cardiomyocytes and in Guinea Pig Isolated Hearts

Author(s) -

Liang Guo,

Jian-Yong Qian,

Rory Abrams,

Hai-Ming Tang,

Thomas Weiser,

Martin Sanders,

Kyle L. Kolaja

Publication year - 2011

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000329966

Subject(s) - guinea pig , electrophysiology , pharmacology , cardiac electrophysiology , myocyte , glycoside , induced pluripotent stem cell , biology , chemistry , medicine , stereochemistry , biochemistry , embryonic stem cell , gene

Monitoring changes in the field potential (FP) of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) following compound administration has been proposed as a novel screening tool to evaluate cardiac ion channel interactions and QT liability. Here we extended the use of FP to evaluate the pharmacological and toxicological properties of cardiac glycosides.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research