Cytokine-Induced Apoptosis of Beta-Thalassemia/Hemoglobin E Erythroid Progenitor Cells via Nitric Oxide-Mediated Process in vitro | Zendy

Wasinee Kheansaard | Zendy; Prapaporn Panichob | Zendy; Suthat Fucharoen | Zendy; Dalina Tanyong | Zendy

Open Access

Cytokine-Induced Apoptosis of Beta-Thalassemia/Hemoglobin E Erythroid Progenitor Cells via Nitric Oxide-Mediated Process in vitro

Author(s) -

Wasinee Kheansaard,

Prapaporn Panichob,

Suthat Fucharoen,

Dalina Tanyong

Publication year - 2011

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000329903

Subject(s) - apoptosis , cytokine , nitric oxide , progenitor cell , immunology , tumor necrosis factor alpha , erythropoiesis , bone marrow , endocrinology , medicine , biology , chemistry , microbiology and biotechnology , stem cell , anemia , biochemistry

β-Thalassemia/hemoglobin E (β-thal/HbE) is a common hereditary anemia in Thailand. Ineffective erythropoiesis due to apoptosis and decreased lifespan of circulating thalassemic red blood cells are the major causes of anemia. Changes to bone marrow microenvironment could contribute to apoptotic events. This study examined the effects of cytokines interleukin-1β, tumor necrosis factor-α and interferon-γ on apoptosis of β-thal/HbE erythroid progenitor cells in vitro, including nitric oxide-mediated apoptotic processes.

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