Downregulation of Bradykinin Type 2 Receptor Expression in Cardiac Endothelial Cells during Senescence | Zendy

Laura Nurmi | Zendy; Hanna M. Heikkilä | Zendy; Heikki Vapaatalo | Zendy; Petri T. Kovanen | Zendy; Ken A. Lindstedt | Zendy

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Downregulation of Bradykinin Type 2 Receptor Expression in Cardiac Endothelial Cells during Senescence

Author(s) -

Laura Nurmi,

Hanna M. Heikkilä,

Heikki Vapaatalo,

Petri T. Kovanen,

Ken A. Lindstedt

Publication year - 2011

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000329615

Subject(s) - downregulation and upregulation , senescence , bradykinin , endocrinology , medicine , endothelial dysfunction , endothelium , endothelial stem cell , receptor , kinin , biology , in vitro , biochemistry , gene

Bradykinin type 2 receptor (BK-2R) knockout mice develop microvascular dysfunction and cardiac hypertrophy. In aged human cardiac microvascular endothelium, dysfunction develops before heart failure symptoms. Since endothelial aging is an independent risk factor for cardiovascular disease, we aimed to clarify the role of kinin receptors in age-related endothelial senescence.

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