Alteration of Pulmonary Artery Integrin Levels in Chronic Hypoxia and Monocrotaline-Induced Pulmonary Hypertension | Zendy

Anita Umesh | Zendy; Omkar Paudel | Zendy; Yuan-Ning Cao | Zendy; Allen C. Myers | Zendy; James S.K. Sham | Zendy

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Alteration of Pulmonary Artery Integrin Levels in Chronic Hypoxia and Monocrotaline-Induced Pulmonary Hypertension

Author(s) -

Anita Umesh,

Omkar Paudel,

Yuan-Ning Cao,

Allen C. Myers,

James S.K. Sham

Publication year - 2011

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000329593

Subject(s) - integrin , pulmonary hypertension , hypoxia (environmental) , extracellular matrix , pulmonary artery , receptor , medicine , endocrinology , biology , pathology , microbiology and biotechnology , chemistry , organic chemistry , oxygen

Pulmonary hypertension is associated with vascular remodeling and increased extracellular matrix (ECM) deposition. While the contribution of ECM in vascular remodeling is well documented, the roles played by their receptors, integrins, in pulmonary hypertension have received little attention. Here we characterized the changes of integrin expression in endothelium-denuded pulmonary arteries (PAs) and aorta of chronic hypoxia as well as monocrotaline-treated rats.

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