CTLA-4 +49A>G Polymorphism Is Associated with Advanced Non-Small Cell Lung Cancer Prognosis | Zendy

BaoLiang Song | Zendy; Yanbing Liu | Zendy; Jie Liu | Zendy; Xianrang Song | Zendy; Zhehai Wang | Zendy; Mingyu Wang | Zendy; Yufang Zhu | Zendy; Jinxiang Han | Zendy

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CTLA-4 +49A>G Polymorphism Is Associated with Advanced Non-Small Cell Lung Cancer Prognosis

Author(s) -

BaoLiang Song,

Yanbing Liu,

Jie Liu,

Xianrang Song,

Zhehai Wang,

Mingyu Wang,

Yufang Zhu,

Jinxiang Han

Publication year - 2011

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000329345

Subject(s) - medicine , genotype , lung cancer , gastroenterology , ctla 4 , cytotoxic t cell , immunology , t cell , gene , biology , immune system , genetics , in vitro

Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a potent immunoregulatory molecule that suppresses antitumor response by downregulating T cell activation. The most studied +49A>G polymorphism of the CTLA-4 gene has been associated with several autoimmune diseases. However, little is known about the association between this functional polymorphism of CTLA-4 and cancer prognosis.

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