Xanthine Oxidase Inhibition Attenuates Endothelial Dysfunction Caused by Chronic Intermittent Hypoxia in Rats | Zendy

John M. Dopp | Zendy; Nathan R. Philippi | Zendy; Noah J. Marcus | Zendy; E. B. Olson | Zendy; Cynthia E. Bird | Zendy; John J. Moran | Zendy; Scott W. Mueller | Zendy; Barbara J. Morgan | Zendy

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Xanthine Oxidase Inhibition Attenuates Endothelial Dysfunction Caused by Chronic Intermittent Hypoxia in Rats

Author(s) -

John M. Dopp,

Nathan R. Philippi,

Noah J. Marcus,

E. B. Olson,

Cynthia E. Bird,

John J. Moran,

Scott W. Mueller,

Barbara J. Morgan

Publication year - 2011

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000329341

Subject(s) - xanthine oxidase , allopurinol , medicine , endocrinology , hypoxia (environmental) , vasodilation , intermittent hypoxia , xanthine oxidase inhibitor , xanthine , endothelium , chemistry , obstructive sleep apnea , oxygen , biochemistry , enzyme , organic chemistry

Xanthine oxidase is a major source of superoxide in the vascular endothelium. Previous work in humans demonstrated improved conduit artery function following xanthine oxidase inhibition in patients with obstructive sleep apnea.

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