Growing Bacteria Shed Elicitors of Drosophila Humoral Immunity | Zendy

Jenny Karlsson | Zendy; Sandra Oldenvi | Zendy; Carina Fahlander | Zendy; Anusara Daenthanasanmak | Zendy; Håkan Steiner | Zendy

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Growing Bacteria Shed Elicitors of Drosophila Humoral Immunity

Author(s) -

Jenny Karlsson,

Sandra Oldenvi,

Carina Fahlander,

Anusara Daenthanasanmak,

Håkan Steiner

Publication year - 2011

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000329224

Subject(s) - peptidoglycan , bacteria , biology , immune system , antimicrobial peptides , innate immune system , microbiology and biotechnology , immunity , drosophila (subgenus) , antimicrobial , biochemistry , immunology , genetics , gene

It has been much debated how the Drosophila immune system can recognize bacterial peptidoglycan that is often hidden. We show that bacteria separated from Drosophila S2 cells by a semipermeable membrane can upregulate the Imd pathway. Supernatants from exponentially growing but not from stationary-phase bacterial cultures induce antimicrobial peptides. It is also made likely that the shed elicitors are of peptidoglycan nature.

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